Iogna Prat L, et al. - In view of the observation that HIV-positive people display a wide spectrum of liver injury, in particular, a higher prevalence of nonalcoholic fatty liver disease (NAFLD) compared with HIV-negative people, researchers undertook this retrospective evaluation of all liver biopsies performed at Royal Free Hospital from 2000 to 2017 in HIV monoinfected patients with abnormal transaminases to determine the underlying cause of liver disease and to characterize the extent of fibrosis. In this work, a surprisingly high number of patients displayed nonsignificant changes or even normal histological findings among HIV-positive patients with elevated transaminases. Compared to the other series reported, this study had a lower prevalence of NAFLD. The number of required biopsies may reduce using noninvasive tools with a high negative predictive value for significant fibrosis.