Al-Sheikh H, et al. - Researchers conducted multiethnic systemic sclerosis (SSc) cohort study in order to assess ethnic variations in disease manifestations, internal organ involvement, and survival. They assessed 1,005 adults who fulfilled the American College of Rheumatology/European League Against Rheumatism classification criteria for SSc between 1970 and 2017. Of these, the majority were European-descent white (n = 745, 74%), Afro-Caribbean (n = 58, 6%), South Asian (n = 70, 7%), and East Asian (n = 80, 8%). Compared with European-descent white adults, calcinosis and esophageal dysmotility were less frequent in East Asians; interstitial lung disease was more frequent in Afro-Caribbeans; and diffuse cutaneous disease and diabetes were mored frequent in First Nations adults. Hispanic adults vs European-descent white adults have better long-term survival. The longest median survival time of 43.3 yrs was noted among East Asians while the shortest median survival time of 15 yrs was observed for Arabs. Afro-Caribbean and European-descent white adults displayed no significant difference in median survival times. These findings suggest that ethnic variations in some SSc disease manifestations does not result in significant differences in short-term survival but may affect long-term survival.