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Ethnic minority disparities in progression and mortality of pre-dialysis chronic kidney disease: A systematic scoping review

BMC Nephrology Jun 12, 2020

Hounkpatin HO, Fraser SDS, Honney R, et al. - Researchers analyzed 55 relevant studies, including 2 systematic review, 7 non-systematic reviews, and 46 individual studies, all identified from 9 databases, to synthesize existing literature on ethnic disparities in progression as well as mortality for adults with pre-dialysis chronic kidney disease (CKD), and to define factors adding to these disparities, as well as to identify gaps in the literature, via this scoping review. As per most studies, there was a higher risk of CKD advancement among Afro-Caribbean/African-Americans, Hispanics, and Asians, lower risk of death in Asians, and there were mixed results on risk of death for Afro-Caribbean/African-Americans and Hispanics, relative to Caucasians. For ethnic minorities, the contributors to increased risk of progression were biological factors such as hypertension, diabetes, and cardiovascular disease, though these did not cause a rise in mortality risk in these groups. Overall, findings revealed that ethnic minorities had higher rates of renal replacement therapy, which may be partially attributable to increased risk of progression as well as decreased mortality in these groups. Through this work, gaps in the literature were identified and a requirement for a more structured approach by researchers was suggested.

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