Jiang H, et al. - Researchers examined the links between risk factors (such as mammographic density, hormone therapy use and family history) and the efficacy of screening mammography with or without clinical breast examination (CBE) in a cohort of women 50–69 years old screened at the Ontario Breast Screening Program using a joint logistic regression. They concluded an increase in the overall sensitivity and decrease in the specificity with the addition of CBE to mammography. CBE can be limited to those for whom it has the highest benefit. They noted the addition of CBE resulted in the average loss of specificity which ranged from 3.6% to 5.7% and the gain of sensitivity that was between 10.6% and 21.2%, for low-risk group (defined as without dense breasts, family history, and not currently using hormone therapy).