Bradley SH, Hatton NLF, Aslam R, et al. - This study was intended to assess the sensitivity and specificity of chest X-ray (CXR) requested by patients who are symptomatic, ascertain the positive predictive values of each presenting symptom of lung cancer after a negative CXR, and ascertain if symptoms linked with lung cancer are different in those who had a positive CXR result compared with those who had a negative CXR result. Researchers designed a prospective cohort study in Leeds, UK, based on routinely collected data from a service that allowed patients with symptoms of lung cancer to request CXR. Out of 8,996, 114 (1.3%) patients who requested a CXR were diagnosed with lung cancer within 1 year. The results exhibited that CXR has limited sensitivity; nevertheless, in a population with a low prevalence of lung cancer, its high specificity, and negative predictive value means that lung cancer is very unlikely to be present following a negative result. Data also suggest guidance that unexplained hemoptysis needs an urgent referral, regardless of the CXR result.