Jones JM, Stone M, Sulaeman H, et al. - Investigation performed using a sample of blood donations in the US from July 2020 through May 2021 revealed an increase in the estimated SARS-CoV-2 seroprevalence over time and its variation by age, race and ethnicity, and geographic region.

• A repeated cross-sectional study was conducted including 1,443,519 blood donation specimens from a catchment area representing 74% of the US population.

• Findings revealed an increase in the estimated SARS-CoV-2 seroprevalence weighted for disparities between the study sample and general population from 3.5% in July 2020 to 20.2% for infection-induced antibodies and 83.3% for combined infection- and vaccine-induced antibodies in May 2021.

• Differences in seroprevalence by age, race and ethnicity, and geographic region of residence were evident.

• However, over the course of the study, changes in these disparities occurred.