Jaywant A, Dunlop K, Victoria LW, et al. - Since white matter hyperintensities (WMH) are linked to deficits in cognitive functioning, including cognitive control and memory, however, the structural and functional mechanisms are largely unexplored, researchers conducted this cross-sectional study to explore the connection between estimated regional disruptions to white matter fiber tracts from WMH, resting-state functional connectivity (RSFC), and cognitive functions in older adults. The interaction of estimated regional WMH burden and RSFC in the default mode network and frontoparietal network cortico-striatal regions was associated with the delayed recall. Models predicting working memory, cognitive inhibition, and set-shifting were found to be insignificant. The findings emphasize the importance of network-level structural and functional changes in resting-state networks that are related to WMH and impact memory in older adults.