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Estimated 24-h urinary sodium and sodium-to-potassium ratio are predictors of kidney function decline in a population-based study

Journal of Hypertension Aug 06, 2019

Deriaz D, Guessous I, Vollenweider P, et al. - Using a longitudinal population-based cohort, researchers focused on the relationship of urinary sodium and potassium excretions with mean estimated glomerular filtration rate variation. They used Kawasaki formulae to estimate 24-h urinary sodium (eUNa), potassium (eUK) and sodium-to-potassium ratio (eUNa/K) from spot urine. The study sample included 4,141 white participants, 54.3% were women. Participants had a median age of 51.5 [43.6–60.6] years and mean baseline estimated glomerular filtration rate 88 (SD 15) ml/min per 1.73 m2. A median follow-up of 5.4 years was carried out. Faster renal function decline was reported in relation to high eUNa and eUNa/K, in the fully adjusted model. In the general adult population, a possible role of dietary sodium and potassium intakes in kidney function decline was suggested.
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