Van Daele DJ - Researchers sought to review high-resolution manometry, pH probe testing, contrast videofluoroscopy, and endoscopy studies retrospectively in patients with primary globus sensation complaints. For patients assessed between 2009 and 2016 with the primary complaint of globus sensation, an inclusive retrospective chart review was conducted. Testing age, self-identified gender, related diagnoses and outcomes were gathered from each modality. One hundred seventy-two patients met the requirements for incorporation. Esophageal manometry found abnormalities in 62.8% of patients, and pH testing found abnormal acidification in about 20%. The esophagram found anomalies in 24% of patients and anomalies in 22% were recognized by esophagogastroduodenoscopy. Findings suggested that isolated globus sensation patients have evidence of esophageal dysmotility and laryngopharyngeal and gastroesophageal reflux disease in high proportions. Esophageal high-resolution manometry testing identifies the highest percentage of anomalies of the modalities investigated.