Xu K, et al. - An investigation was initiated with regard to the predictive factors of recurrent proliferative vitreoretinopathy (PVR) formation and the necessity of additional vitreoretinal surgical intervention after uncomplicated primary retinal detachment (RD) repair. Both epiretinal membrane (ERM) and cystoid macular edema (CME) were disclosed as potential predictive factors for recurrent PVR formation after uncomplicated primary RD repair. It was suggested that early detection and treatment of ERM and CME could be crucial for the prevention of subsequent PVR formation and for bringing about an improvement in the visual outcomes.

Methods

• The plot of this research was a retrospective single-center case-control study.
• The enrollees included consecutive patients with PVR formation after uncomplicated RD repair.
• Logistic regression inspected the factors related to recurrent PVR formation.

Results

• This study recruited thirty-seven eyes (37 patients) who had recurrent RD secondary to PVR formation.
• 27 eyes required one additional surgery. In contrast, the remainder 10 eyes required two or more additional surgeries.
• Patients with cystoid macular edema (CME) after the second surgery exhibited 8.33 times (crude odds ratio [COR], 95% confidence interval [CI]: 1.23-56.67, p=0.0302) greater tendency of presenting with recurrent PVR formation than those who did not have CME after the second surgery, revealed by the univariate analysis.
• Similarly, those who had epiretinal membrane (ERM) after the second surgery illustrated 8.00 times (COR, 95% CI: 1.43-44.92, p=0.0182) greater likelihood of recurrent PVR formation compared to those who did not have ERM after the second surgery.
• In the multivariate analysis, the development of recurrent PVR was 8.20 times (adjusted odds ratio [AOR], 95% CI: 1.08-62.40, p=0.0422) more likely in patients who had ERM after the second surgery than those who did not have ERM after the second surgery, when adjusted for age, sex, and CME after the second surgery.