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Epidemiology of COVID-19 in pregnancy: Risk factors and associations with adverse maternal and neonatal outcomes

American Journal of Obstetrics and Gynecology Sep 30, 2020

Brandt JS, Hill J, Reddy A, et al. - Via performing a matched case-control study of pregnant patients with confirmed COVID-19 (cases) who delivered between 16 and 41 weeks’ gestation, researchers sought to quantify the correlations of COVID-19 with adverse maternal and neonatal outcomes in pregnancy. in addition, they characterized the epidemiology and risk factors. From March 11-June 11, 2020, they identified 61 confirmed COVID-19 cases for inclusion (mild disease: n = 54, 88.5%; severe disease: n = 6, 9.8%; and critical disease: n = 1, 1.6%). Controls were uninfected pregnant women who were matched to COVID-19 cases on a 2:1 ratio based on delivery date. Findings revealed correlation of COVID-19 during pregnancy with elevated risk for adverse maternal and neonatal outcomes, a correlation that is primarily driven by morbidity linked with severe/critical COVID-19. Risk factors for associated morbidity were Black and Hispanic race, obesity, advanced maternal age, medical comorbidities, and antepartum admissions related to COVID-19.

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