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Epidemiology of coronavirus disease 2019 in pregnancy: Risk factors and associations with adverse maternal and neonatal outcomes

American Journal of Obstetrics and Gynecology Oct 16, 2020

Brandt JS, Hill J, Reddy A, et al. - Via performing a matched case-control study of pregnant patients with confirmed coronavirus disease 2019 cases who delivered between 16 and 41 weeks’ gestation, researchers sought to estimate the correlations of coronavirus disease 2019 with adverse maternal and neonatal outcomes in pregnancy. In addition, they characterized the epidemiology and risk factors. During the study period, enrollment of a total of 61 confirmed coronavirus disease 2019 cases was done (mild disease, n = 54 [88.5%]; severe disease, n = 6 [9.8%]; critical disease, n = 1 [1.6%]). Controls were uninfected pregnant women matched to coronavirus disease 2019 cases on a 2:1 ratio based on delivery date. Outcomes revealed an elevated risk of adverse maternal and neonatal outcomes in association with coronavirus disease 2019 during pregnancy; this association is noted to be primarily driven by morbidity associated with severe or critical coronavirus disease 2019. Following factors were noted to be linked with the risk of morbidity: Black and Hispanic race, obesity, advanced maternal age, medical comorbidities, and antepartum admissions related to coronavirus disease 2019.

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