Ramsey NB, et al. - Researchers define the largest cohort of intensive care unit pediatric anaphylaxis admissions by analyzing recognized triggers, clinical and demographic data, and the likelihood of mortality in a comprehensive analysis. They used the 2010-2015 Virtual Pediatric Systems database to select prospectively enrolled pediatric anaphylaxis admissions to North American pediatric intensive care units (PICUs). Of 604,279 patients admitted to a PICU in the database during this time duration, they identified 1,989 patients younger than 18 years. Peanuts, milk, and blood products were identified as triggers for fatal cases. The most common trigger was peanuts. An average length of stay of 2 days was reported. This study represents the largest investigation to report pediatric critical anaphylaxis cases in North America. Food was identified as the most common trigger. The occurrence of death was reported in 1% of cases. In most cases, intubation occurred in the first hour. The serious nature of anaphylaxis in this populace was emphasized by the observed risk for intensive care unit admission in children.