Arapović A, Vukojević K, Filipović N, et al. - In this study performed on a pediatric population in the Croatian region of Dalmatia, researchers compared the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from children. A total of 54 of 231 pediatric patients with suspected glomerular and tubulointerstitial diseases underwent renal biopsy, guided by ultrasound, at the University Hospital of Split. This study did not include kidney allograft biopsy and re-biopsy. A retrospective analysis of kidney biopsy data from 2008 to 2017, vs that between 1995 and 2005, was performed. The children involved in this study had a mean age of 9.84 ± 5.4 years. Pure nephrotic syndrome without hematuria (25.9%), non-nephrotic proteinuria with haematuria (22.2%), nephritic syndrome with nephrotic proteinuria (18.5%), and isolated hematuria (16.7%) were all reported as the main indications for biopsy. The observed shifts in the epidemiology of renal diseases in children between the examined periods revealed that IgA nephropathy, minimal change disease, Henoch-Schönlein purpura glomerulonephritis, Alport syndrome and focal segmental glomerulosclerosis displayed a rising trend, while for mesangioproliferative glomerulonephritis and endoproliferative glomerulonephritis, a decreasing trend was observed that can be explained with the novel pathohistological classification.