Hong SA, et al. - Authors wanted to describe the epidemiology of primary laryngeal lymphoma and determine the prognostic factors affecting survival in patients with this disease. Independent positive prognostic indicators for survival were determined to be female sex and lower Ann Arbor staging. Experts noted no other clinical variables, such as grade and histology, impacted survival. In patients with primary laryngeal lymphoma, radiation and chemotherapy did not seem to offer a mortality benefit.

Methods

• This was a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database, using cases from 1973 to 2014.
• Researchers conducted a population-based analysis with patients from more than 15 different geographic regions across the United States.
• Patients with a diagnosis of lymphoma and a primary lymphoma site within the larynx were chosen for the study.
• Based on the inclusion criteria, 200 cases were eligible, and characteristic as well as clinical variables (including age, race, sex, primary site of lymphoma involvement, general histology, specific histologic subtype, tumor grade, and Ann Arbor staging) were then extracted from the database and analyzed.
• The analyzed exposure variables included radiation therapy and chemotherapy.
• The main outcomes calculated using multivariate analysis were the overall survival (OS) and disease-specific survival (DSS).

Results

• A total of 200 cases of laryngeal lymphoma were identified, 64.2 years was the mean age at diagnosis, and 53% were males.
• Experts noted that 74% of cases were B-cell non-Hodgkin's lymphoma (NHL), and 10% were natural killer/T-cell NHL.
• Radiation therapy was received by 53.1% of patients; chemotherapy was received by 47.5%.
• Data demonstrated the median OS to be 9.15 years and median DSS to be 24.5 years; OS at 2, 5, and 10 years was 74%, 63%, and 44%, respectively.
• On multivariate analysis, older age, male sex, and advanced Ann Arbor staging was linked to worse OS; only male sex and advanced Ann Arbor staging were associated with worse DSS (all P values < .05).
• Researchers did not note any association of radiation and chemotherapy with improved survival.