Gadre SK, et al. - Using a large administrative database inclusive of patients of all ages and insurance status, researchers described the associated etiology and risk factors for readmission in patients with sepsis. The most commonly associated cause for 30-day readmission was infectious etiology, followed by gastrointestinal, cardiovascular, pulmonary, and renal causes. Diabetes, chronic kidney disease, congestive heart failure, discharge to short-/long-term facility, Charlson comorbidity index ≥ 2, and length of stay ≥ 3 days during the index admission were included significant predictors associated with increased 30-day readmission. According to findings, the mean cost per readmission was $16,852; annual cost was > $3.5 billion within the United States. Readmission was found to be both common and expensive following sepsis hospitalization. Infectious etiologies were associated with the majority of readmissions. The striking rate of readmission requires efforts to further clarify readmission determinants and to develop quality care and care transitions strategies to prevent this outcome.