Macauley P, et al. - The epidemiology and mycology of invasive candidiasis in the ICU has been scarcely studied is non‐neutropenic patients admitted specifically to medical ICUs. Even less information is there concerning the broader category of medical ICU patients without active oncological disease. In this study, medical ICU candidemia episodes that occurred in non‐oncological patients from May 2014 to October 2020 in researchers’ tertiary academic centre in the United States were studied in order to ascertain the incidence and species distribution of the linked isolates. Thereafter, they considered non‐COVID‐19 and COVID‐19 cases separately and performed comparison of their characteristics. Non‐COVID‐19 group and the COVID‐19 group had 38 cases vs 12 cases for an incidence of 1.1% vs 5.1% and rate of 11/1000 vs 51/1000 admissions, respectively. Candida albicans accounted for a minority of isolates in the entire sample, as well as separately in the non‐COVID‐19 and COVID‐19 groups. COVID‐19 patients with candidemia were noted to have lower ICU admission SOFA score but longer ICU length of stay and central venous catheter dwell time at candidemia detection when compared with non‐COVID‐19 patients with candidemia.