Gergianaki I, et al. – This report highlighted the systemic lupus erythematosus (SLE) epidemiology and burden on the island of Crete between 1999–2013. With the aid of a comprehensive methodology, the authors illustrated the full spectrum of SLE from the community to tertiary care, with almost half of the cases having mild disease, yet with significant damage accrual. SLE was not rare, it affects predominantly middle–aged women and was increasingly recognised in men. In lupus prevention and care, neuropsychiatric disease was an emerging frontier.