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Eosinophilic Granulomatosis with Polyangiitis: Clinical predictors of long-term asthma severity

Chest Jan 25, 2020

Berti A, Cornec D, Moura MC, et al. - By performing this retrospective cohort analysis, researchers characterized long-term asthma in Eosinophilic Granulomatosis with Polyangiitis (EGPA) as well as explored baseline predictors of long-term asthma severity. This study included 89 patients having EGPA, with a documented asthma evaluation at baseline and at 3 years from diagnosis. Experts detected severe/uncontrolled asthma in 42.7% of patients at diagnosis, which was found to be related to a prior history of respiratory allergy, raised serum total IgE levels, increased use of high dose inhaled and oral corticosteroids for respiratory symptoms the year prior to the diagnosis of EGPA. The identified independent predictors of severe/uncontrolled asthma at the 3-year endpoint were: severe rhinosinusitis, pulmonary infiltrates, overweight and severe/uncontrolled asthma at vasculitis diagnosis, as revealed on multivariate binary logistic regressions. Findings revealed a link of long-term severe/uncontrolled asthma with baseline pulmonary and ENT manifestations, but not with clear-cut vasculitic characteristics, among asthmatic patients with EGPA.
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