Manna LB, Ovadia C, Lövgren-Sandblom A, et al. - Researchers sought to assess the utility of quantification of enzymatic total serum bile acid as a monitoring strategy for women with intrahepatic cholestasis of pregnancy (ICP) treated with ursodeoxycholic acid (UDCA). In this cohort study, 29 ICP cases treated with UDCA were included. Serial samples collected prospectively throughout gestation were assessed for total serum bile acids measured enzymatically and for individual bile acids by high-performance liquid chromatography-tandem mass spectrometry. Outcomes revealed that cholic acid (51%) was the principal bile acid in untreated women, while ursodeoxycholic acid (60%) became the main component of the bile acid measurement following treatment. The predictive value of enzymatic total bile acid assays is good for both cholic acid and chenodeoxycholic acid, the primary bile acids that are raised prior to treatment.