Meinel TR, Kniepert JU, Seiffge DJ, et al. - Researchers conducted this multicenter observational cohort study to determine the safety and mortality after mechanical thrombectomy in patients (n = 1,932; median age was 74 years) taking vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs). To assess relationships of symptomatic intracranial hemorrhage (sICH) with VKA or DOAC prescription before thrombectomy as compared with no anticoagulation, multiple logistic regression analysis was used. In contrast with the control group, VKA prescription was correlated with increased chances of sICH and mortality, whereas no relationship with DOAC intake was seen. After mechanical thrombectomy, patients taking VKA have an increased risk of sICH and mortality. In the acute setting also the lower risk of sICH associated with DOAC may be evident. Improved selection in patients treated with VKA could be advisable.