Batko K, et al. - Researchers examined the link between endothelial injury and a biochemical panel including serum (soluble) thrombomodulin (sTM), intact parathormone, interleukin-6, pentraxin 3, fibroblast growth factor 23, osteopontin (OPN), osteoprotegerin, osteocalcin, osteonectin, soluble tumor necrosis factor receptor type 2 (TNFR2), transforming growth factor-β, hepatocyte growth factor, vascular endothelial growth factor receptor type 2 and stromal cell-derived factor 1α in consecutively recruited 80 patients in end stage renal disease. Findings revealed a close association of OPN and TNFR2 with sTM, suggesting a possible link between endothelial damage, vascular remodeling and inflammation. Additionally, the progression of radial artery calcification paralleled a presumed compensatory surge in sTM, indicating endothelial injury. An intricate role of sTM in endothelial function, as well as its potential clinical and prognostic importance, was suggested in this study.