Saratziotis A, Emanuelli E, Zanotti C, et al. - Researchers conducted this prospective cohort study to assess the effect of endoscopic sinus surgery (ESS) on clinical outcomes, quality of life (QoL), and Nasal Obstruction and Symptom Evaluation (NOSE) scale in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and CRSsNP and chronic rhinosinusitis without nasal polyps (CRSsNP). In addition, they aspired to explore whether there is a relationship between patients at the age of relapse. The sample consisted of 150 patients [96 males, 54 females, mean age: 51.99 ± (15.73)]. In order to measure the patients’ QoL and their nasal blockage symptoms, respectively, the SNOT-22 and NOSE questionnaires were used. Following ESS, the endoscopic scale exhibited a significant improvement in 83.85% of patients. No statistically significant association was found between age, gender, smoking, and recurrence tendency. For symptomatic patients with CRSwNP and CRSsNP, ESS is an important treatment choice. Significantly improved both objective and subjective measurements, including QoL, and stabilized results at 12 to 18 months. In the CRS population, the NOSE scale is a sensitive outcome measure including individuals with and without nasal polyps. SNOT-22 and NOSE are outstanding predictors of postoperative improvement in the study.