Bischoff S, et al. - Researchers, in an Emergency Department, examined the clinical risk factors for antimicrobial resistances and multidrug resistance (MDR) in urinary tract infections (UTI) in order to improve empirical therapy. In this study, several risk factors (residence in nursing homes, male gender, hospitalization within the last 30 days, renal transplantation, antibiotic treatment within the last 30 days, indwelling urinary catheter and recurrent UTI) for resistances and MDR in UTI were identified. These risk factors were influencing the susceptibility towards antimicrobials. Cephalosporins appeared to be the best choice for empiric therapy with no risk factor. However, in patients with risk factors the beta-lactam penicillin Piperacillin with Tazobactam was an equal or better choice compared to fluoroquinolones, cephalosporins or gentamicin. In order to improve empiric therapy in a local environment, findings thus underscore the importance of monitoring local resistance rates and its risk factors.