Damiano JA, Deng L, Li WH, et al. - Researchers investigated the prevalence of SCN1A (sodium channel gene) variants in children with their first febrile seizure either proximal to vaccination, or unrelated to vaccination vs controls, given febrile seizures may occur after vaccination. They used a prospective cohort including children presenting with their first febrile seizure as vaccine proximate (n = 69), or as non-vaccine proximate (n = 75). They also examined children with no history of seizures (n = 90) selected in Australian paediatric hospitals. In vaccine proximate cases, they found two pathogenic variants (p.R568X and p.W932R), both of whom contracted Dravet syndrome, and they identified one in a non-vaccine proximate case (p.V947L) who suffered Febrile seizures plus from 9 months. In children with febrile seizures vs controls, the enrichment of a reported risk allele, rs6432860-T, was identified. Experts concluded that in infants with vaccine proximate febrile seizures, pathogenic SCN1A variants may be found. Given the importance of early diagnosis of Dravet syndrome in order to ensure optimal management and outcome, routine SCN1A sequencing was recommended in infants with prolonged febrile seizures, proximate to vaccination.