Yeh WC, et al. - A total of 398 individuals who finished a questionnaire that incorporated personal and medical history data, and an anthropometric measurement and blood sampling, were enrolled in order to examine the relationship between triglyceride to HDL-cholesterol (TG/HDL-C) and insulin resistance (IR, most prevalent characteristic of obesity, is a major pathophysiological factor in the development and progression of DM and cardiovascular disease) (as estimated by homeostasis model evaluation of IR [HOMA-IR]), and ascertain a clinical prognostication rule for IR in middle-aged and old Taiwanese. Between IR and TG/HDL-C ratio, a meaningful correlation was recognized. High BMI, hypertension, DM, and high TG/HDL ratio were significantly related to the risk of raised HOMA-IR in multiple logistic regression. In conclusion, the findings explicated that among the middle-aged and old age population in Taiwan, the raised TG/HDL-C ratio was significantly related to IR and could be utilized as an indicator of IR. Moreover, it is clinically available, therefore, excluding any extra costs.