Aluko A, et al. - Via conducting a retrospective cohort study of autologous fresh IVF cycles resulting in delivery, researchers investigated how serum progesterone on the day of human chorionic gonadotropin (hCG) administration is correlated to the risk of ischemic placental disease [IPD; preeclampsia, placental abruption, and/or small for gestational age (SGA)] or an intrauterine fetal demise due to placental insufficiency. Outcomes revealed 143 deliveries among patients with the lowest tertile of progesterone (0.2-0.73 ng/ml), 148 deliveries in the middle tertile (0.65-1.05 ng/ml) and 142 deliveries in the highest tertile (1.06-5.6 ng/ml). Elevated serum progesterone on the day of hCG administration in fresh IVF cycles was noted to be correlated with an enhanced risk of IPD and preeclampsia.