Shui X, Wen Z, Chen Z, et al. - This study demonstrates a positive and independent link of elevated baseline serum lipoprotein(a)[Lp(a)] with angiographic progression of coronary artery disease (CAD), especially in participants with relatively low body mass index. Thus, Lp(a) could represent a potent risk factor for CAD progression, helping in early risk stratification in cardiovascular cases.

• Participants were 814 patients who had undergone two or more coronary computed tomography angiography at least 6 months apart.

• Using the Gensini score system, coronary severity was recorded.

• Patients were divided as Lp(a)>300 mg/L and Lp(a) ≤ 300 mg/L or as “progressors” and “non-progressors” considering the Gensini score rate of change per year.

• Significantly higher Lp(a) levels were detected in the “progressors” group.

• In multivariate logistic regression analysis, increased Lp(a) (odds ratio [OR]: 1.451) and Lp(a)>300 mg/L (OR:1.642) were positively related to CAD progression post-adjusting for confounding factors.

• Those links appeared to be more prominent in participants with lower BMI (OR: 1.880).