Ohara T, Furuta Y, Hirabayashi N, et al. - In the present study, the researchers sought to explore the correlation of alternative glycemic measures – namely, serum glycated albumin (GA), hemoglobin A_1c (HbA_1c) and the GA : HbA_1c ratio – with global brain and hippocampal atrophy in a general elderly Japanese population. In total, 1,278 Japanese people aged ≥ 65 years in a community partook in brain MRI scanning and screening examination of health status in 2012. According to results, the mean values of the TBV : ICV and HV : ICV ratios declined significantly with raising serum GA levels and GA : HbA_1c ratio levels, but not with higher HbA_1c levels, after adjusting for age, gender, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, BMI, smoking habits, alcohol drinking habits, and regular exercise. Findings suggested a significant association of higher serum GA and higher GA : HbA_1c ratio with global brain and hippocampal atrophy.