Al Smadi MA, Hammadeh ME, Batiha C, et al. - This study’s findings demonstrate that sperm motility and laboratory intracytoplasmic sperm injection (ICSI) outcomes are affected negatively by higher concentrations of protein carbonyl (PC) in the semen.

• Researchers recruited a total of 150 couples from the ICSI cycle in this study and were classified into three groups (G) according to the PC concentration as following, G1 included samples with PC concentrations <0.65 nmol/mg, G2 included samples with 0.65≤PC≤2.23 nmol/mg and G3 included samples with PC>2.23 (nmol/mg).

• They assessed PC concentrations in all semen samples, and the laboratory ICSI outcomes were assessed for all injected oocytes.

• It has been reported that Kruskal–Wallis p-values for the differences in the medians of sperm motility, fertilization rate, embryo cleavage score, and embryo quality score were <0.05.

• As per the findings, Dunn's post hoc test indicated a significant difference between all groups, p-values <0.05, except for the medians of embryo quality score between G2 and G3.