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Elevated pulmonary artery pressure, not pulmonary vascular resistance, is an independent predictor of short-term morbidity following bidirectional cavopulmonary connection

Pediatric Cardiology Jun 20, 2018

Tran S, et al. - Given mean pulmonary artery pressure (MPAP) and indexed pulmonary vascular resistance (PVRi) were two measures that impact pulmonary blood flow following bidirectional cavopulmonary connection (BCPC), the researchers determined which hemodynamic features were correlated with adverse outcomes after BCPC. From 2008 to 2014, they reviewed pre-operative hemodynamic data and post-operative morbidity and mortality in 250 subjects undergoing BCPC at a single center. Findings revealed that elevated MPAP, need for pre-operative oxygen support, sildenafil use, and systemic ventricular systolic dysfunction predicted morbidity following BCPC. The highest risk of morbidity and mortality was found in patients with elevated MPAP, not due to elevated PVRi or pulmonary blood flow.
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