Zhu Y, et al. - Using an inverse-weighted method, researchers undertook single and combined multiple instrumental variable Mendelian randomization analysis in order to gain clarity regarding the causal link between platelets and risk of lung cancer. They also carried out a series of sensitivity analyses. They analyzed data from a recent publication that included 48,666 Caucasian Europeans, as well as data comprising 29,266 cases and 56,450 controls from the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung to examine links between candidate SNPs and lung cancer risk. For overall non–small cell lung cancer and for small-cell lung cancer, a 62% and 200% increased risk, respectively, was observed in multiple instrumental variable analysis including six SNPs. A causal link between elevated platelet count and increased risk of lung cancer was evident. This study offered evidence of possible antiplatelet interventions for lung cancer prevention.