Kumar NP, et al. - Researchers aimed at studying the association of matrix metalloproteinase (MMP) levels with severity and extent of disease as well as bacterial burden in tuberculosis – diabetes comorbidity (TB-DM) via examining the systemic levels of MMP-1, -2, -3, -7, -8, -9, -10, -12 and -13 in individuals with TB-DM and comparing them to those with TB alone (TB) or healthy controls (HC). In this work, systemic MMP levels were identified reflecting baseline disease severity and extent in TB-DM. The levels were also helpful in differentiating those known to be diabetic before incident TB (KDM) from those with newly diagnosed DM (NDM) and were modulated by anti-tuberculosis therapy (ATT) and metformin therapy.