Oh JY, et al. - Given acute exacerbation is an important factor in the management of tuberculosis-destroyed lung (TDL), researchers assessed the factors related to acute exacerbations in patients with stable TDL with airflow limitation. A total of 94 patients with TDL with chronic airflow limitation were examined for clinical characteristics (eg, function, image findings, and serum laboratory findings), including C-reactive protein, erythrocyte sedimentation rate, and interleukin-6. The investigators that patients with exacerbation were more likely to have bronchiectasis as well as significantly higher levels of CRP and IL-6 vs those without exacerbation. The most important parameters associated with acute exacerbation were bronchiectasis and elevated IL-6 levels. The authors suggested that more intensive treatment may be needed to prevent acute exacerbation in patients with bronchiectasis and high IL-6 levels.