Liu Y, Zhang S, Xia CS, et al. - This study was intended to assess the levels of granulocyte colony-stimulating factor (G-CSF), an essential regulator of neutrophil production and function, in the pathogenesis of adult-onset Still disease (AOSD). Researchers collected sera from 70 patients with AOSD and 20 healthy controls. Via ELISA, the levels of G-CSF were ascertained. They evaluated low-density granulocytes (LDGs) by flow cytometry. A Spearman correlation test was used to examine associations between G-CSF levels and disease activity, laboratory variables, and LDG levels in patients with AOSD. The data demonstrate that G-CSF is implicated in the pathogenesis of AOSD, and targeting G-CSF may have therapeutic potential for AOSD. Outcomes suggest that introducing circulating G-CSF levels into the clinical assessment system may help to monitor disease activity.