Thanapluetiwong S, Ruangritchankul S, Sriwannopas O, et al. - This study was carried out to assess the effectiveness of quetiapine use to prevent delirium in hospitalized older medical patients. Researchers designed a randomized double-blind controlled trial at Ramathibodi Hospital, Bangkok, Thailand. The primary outcome included incidence of delirium. Delirium duration, length of hospital stay, ICU admission, rehospitalization, and mortality within 30 and 90 days were considered as secondary outcomes. The study included 122 patients. In hospitalized older medical patients, quetiapine prophylaxis did not reduce delirium incidence. In this population group, the use of quetiapine to prevent delirium is not be recommended. The delirium incidence rates in the quetiapine and placebo groups were 14.0 and 8.8%, respectively.