Sinawat S, Jumpawong S, Ratanapakorn T, et al. - In this investigation involving 155 patients (158 eyes), researchers sought to determine an anatomical hole closure and a visual outcome after surgical treatment of large idiopathic full-thickness macular holes (FTMH), and also assess the predictive factors and the possible adverse events which are caused by a disease progression or related to treatment. Pars plana vitrectomy with conventional internal limiting membrane peeling (ILMP) for large FTMH showed a relatively low closure rate. Basal linear diameter ≤ 1200 μm, no preoperative vitreomacular interface abnormality, extended ILMP and postoperative ellipsoid defect ≤ 500 μm were significantly associated with surgical success. The authors, therefore, suggest an extended ILMP if the conventional ILMP technique is used. There were significantly better surgical results for the large FTMH group than for the extra-large group, so there is a need for reclassification of the large FTMH group.