Nakano FA, et al. - In this randomized, double-blind, placebo-controlled clinical trial, researchers evaluated pain and determined the efficacy of misoprostol, compared with placebo, for postmenopausal women before diagnostic hysteroscopy. They analyzed 158 postmenopausal women who received either 200 μg of misoprostol or placebo through the vaginal route before diagnostic hysteroscopy (79 women/group). Outcomes suggested that misoprostol results in no reduction in pain intensity, the duration of the procedure, or need for additional cervical dilatation. in addition, more adverse effects were also noted with it when used in these women before diagnostic hysteroscopy