Nagendrababu V, et al. - In this study, the authors assessed the data to quantify the best pulpal anesthetic solution for Inferior Alveolar Nerve Blocks (IANB) treating mandibular teeth with irreversible pulpitis. They studied over anesthetic solutions like lidocaine (lignocaine), articaine, bupivacaine, prilocaine or mepivacaine, used for IANB during root canal treatment. They observed mepivacaine with epinephrine with the highest success rate of giving effective pulpal anesthesia using IANB for teeth with irreversible pulpitis.