Krisanapan P, et al. - In this open-label randomized controlled study, researchers ascertained if, combined with fluid restriction, furosemide with or without sodium chloride (NaCl) supplementation was more effective than fluid restriction alone in the treatment of hyponatremia in syndrome of inappropriate antidiuresis (SIAD). Participants in the study were 92 patients (FR, n = 31; FR +FM, n = 30; FR+FM+NaCl, n = 31) with serum sodium concentrations ([Na⁺]) ≤ 130 mmol/L due to SIAD. In patients with SIAD, furosemide with NaCl supplement in conjunction with fluid restriction showed no advantage in [Na⁺] correction compared with fluid-restricting treatment alone. Patients receiving furosemide have an increased rate of acute kidney injury and hypokalemia.