Toren-Wielema M, et al. - Since the prevalence of vitamin D deficiency in nursing home residents ranges from 79% to 98%, researchers investigated whether an adequate and safe vitamin D trough level (VDTL)—defined as 75–220 nmol/L (reference range)—could be obtained and maintained in somatic and psychogeriatric nursing home residents by administering a standardized oral vitamin D dosing regimen (VDDR) consisting of a loading dose (LD) of cholecalciferol 200,000 IU followed by a maintenance dose (MD) of 100,000 IU every 13 weeks. In this cross-sectional observational study, they looked for the percentage of nursing home residents with a VDTL of 75–220 nmol/L, with a target percentage of 85%, for the dosing regimen to be considered efficacious. Findings demonstrated the inefficacy of this standardized VDDR in obtaining and maintaining an adequate VDTL in this nursing home resident population.