Lu Z, et al. - A prospective, randomized, single-blinded preliminary trial was performed to assess and analyze the sedative effect and the safety of a dexmedetomidine–remifentanil (DR) regimen with a midazolam–remifentanil (MR) combination during the endoscopic retrograde cholangio-pancreatography (ERCP) requiring conscious sedation. This trial was conducted on one-hundred and ninety-eight patients. The authors discovered that the dexmedetomidine–remifentanil protocol provided a parallel sedative efficacy and improved respiratory sparing effects. They reported that the higher patient satisfaction scores potentially offer a more reproducible ERCP quality. During ERCP, adding dexmedetomidine to remifentanil could be used reliably as a conscious sedation method.