Brown HE, et al. - Among patients with schizophrenia with some degree of treatment resistance, researchers examined intravenous sodium nitroprusside (SNP) infused at a rate of 0.5 μg/kg/min for 4 hours for its effectiveness and tolerability. Fifty-two adults with chronic schizophrenia treated with antipsychotic medication were included in this multicenter, randomized double-blind clinical trial. As per outcomes, a 4-hour sodium nitroprusside infusion at 0.5 μg/kg/min led to no improvement in positive, negative, or cognitive symptoms, indicating that it is not efficacious for these patients; no differences in response were evident when stratification was done by clozapine treatment status either. Overall, the patients showed good tolerability to treatment.