Jault P, et al. - In view of the consideration of bacteriophages, natural bacterial viruses, as an alternative therapy to treat infections caused by multidrug-resistant bacteria, researchers compared the efficacy and tolerability of a cocktail of lytic anti- Pseudomonas aeruginosa bacteriophages with standard of care for patients with burns. In this randomised phase 1/2 trial, patients with a confirmed burn wound infection from nine burn centers in hospitals in France and Belgium, were randomly assigned (1:1) to a cocktail of 12 natural lytic anti- P aeruginosa bacteriophages (PP1131; 1 × 10⁶ plaque-forming units [PFU] per mL) or standard of care (1% sulfadiazine silver emulsion cream), both given as a daily topical treatment for 7 days, with 14 days of follow-up. PP1131, at very low concentrations, reduced bacterial burden in burn wounds at a slower pace when compared to the standard of care.