Boric K, et al. - The range of efficacy and safety outcomes used in systematic reviews (SRs) of randomized controlled trials (RCTs) of interventions for postoperative pain in children was investigated and compared with outcome domains recommended in the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (PedIMMPACT). Two review authors extracted outcome data independently via searching five electronic databases: MEDLINE, Cochrane Database of Systematic Reviews, DARE, CINAHL, and PsycINFO. Inclusion of 48 systematic reviews with data from 816 trials was done. “Symptoms and adverse events” was the most commonly reported outcome of the PedIMMPACT Core Outcome set (COS), followed by pain intensity, which was reported in 75% of the included SRs. In the field of pediatric pain, systematic reviews neither used the recommended COS nor consistently included pain as an outcome, making comparisons of efficacy and safety across interventions very difficult.