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Efficacy and safety of tranexamic acid in geriatric hip fracture with hemiarthroplasty: A retrospective cohort study

BMC Musculoskeletal Disorders Jul 04, 2019

Xie J, et al. - Through a cohort study of hip fracture of 289 patients (≥65 years) who underwent hemiarthroplasty between January 2013 and September 2016, the researchers targeted to assess the efficiency and safety of tranexamic acid (TXA) in geriatric hip fracture with hemiarthroplasty (most common surgeries for elderly hip fracture patients). Patients were randomized into the TXA group and control group. A significantly lower proportion of subjects in the TXA group received at least 1U of erythrocytes as that of the control group. In the TXA group on a postoperative day 1 and postoperative day 3, markedly higher mean Hb level was noticed. A significantly greater proportion of TXA patients started to ambulate within 24 h post-surgery and their length of hospitalization was markedly shorter. Also, no increase in the risk of deep venous thrombosis was observed in the TXA group. A total of 62% of the lower risk of red blood cell transfusion was linked to TXA. Hence, for decreasing blood loss and red blood cell transfusion in geriatric hip fracture patients undergoing fast-track hemiarthroplasty, TXA seemed to be secured and efficient.
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