Tsutsui K, Kikuchi K, Nozawa K, et al. - In this multicenter, phase II trial, researchers tested the safety and effectiveness of topical benzoyl peroxide for epidermal growth factor receptor inhibitor-induced prolonged acneiform eruptions. Patients with colorectal, non-small lung cell and head and neck cancers who had persistent acneiform eruptions after taking epidermal growth factor receptor inhibitors for >10 weeks were eligible for the analysis. For 8 weeks, topical benzoyl peroxide was applied to the affected region of the face once daily, with a clinical examination every 2 weeks. There were no serious complications in any of the patients. Overall, topical benzoyl peroxide can be useful for treating and managing prolonged acneiform eruptions caused by epidermal growth factor receptor inhibitors.