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Efficacy and safety of tigecycline for Mycobacterium abscessus disease

Respiratory Medicine Oct 12, 2019

Kwon YS, et al. - Whether tigecycline affords a safe and efficacious treatment option for patients with Mycobacterium abscessus disease, was investigated in this study. For patients with M. abscessus disease taking tigecycline-containing regimens at National Jewish Health from January 2009 to December 2017, researchers carried out retrospective chart reviews. Overall participants were 35 patients. The majority of the patients presented with pulmonary disease (n = 29, 82.9%). Gastrointestinal side effects, including nausea, vomiting, and diarrhea were most commonly experienced adverse drug reactions. A high rate of symptomatic and radiological improvement was reported in relation to treatment with tigecycline-containing regimens. However, the observed poor microbiological response and the common adverse effects call for care while selecting patients for tigecycline treatment and monitoring for adverse drug reactions.
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