Park R, Ho AMH, Pickering G, et al. - In this review, the efficacy and safety of magnesium in chronic pain was examined. Researchers included a total of 9 randomized controlled trials (RCTs) comparing magnesium (at any dose, frequency, or route of administration) with placebo using participant-reported pain measures; the 9 RCTs involved 418 participants. Neuropathic pain was examined in three studies (62 participants), migraines in 3 (190 participants), complex regional pain syndrome in 2 (86 participants), and low back pain with a neuropathic component in 1 (80 participants). No meta-analysis could be done because of the observed heterogeneity. As the included studies inconsistently reported adverse events, no judgment could be made about safety. They gained equivocal evidence of analgesic efficacy from included studies. However, some of the included trials reported efficacy signals providing a rationale for more definitive studies.