El-Hamd MA - Expert assessed the effectiveness and safety of the once-daily use of 5 mg tadalafil in the treatment of patients with premature ejaculation (PE). A single-blind placebo-controlled clinical study on 100 patients with PE was conducted. Significantly higher mean values of the seven questions and total scores of Arabic Index of Premature Ejaculation (AIPE) questionnaire were seen in tadalafil group vs placebo group after treatment. Findings suggested the effectiveness and well tolerability of 5 mg tadalafil for 6 weeks in the treatment of patients with PE.